COMBINED DENDRITIC CELL AND ANTI-TIGIT IMMUNOTHERAPY POTENTIATES ADAPTIVE NK CELLS AGAINST HIV-1

ABSTRACT: Natural Killer (NK) cells are promising candidates for targeting persistently infected CD4+ T cells in people with HIV-1 (PWH). However, chronicity of HIV-1 infection impairs NK cell functionality, requiring additional strategies to potentiate their cytotoxic activity. This study demonstrates that dendritic cells primed with nanoparticles containing Poly I:C (Nano-PIC-MDDC) enhance the natural cytotoxic function of NK cells from effective responder PWH. These NK cells exhibit increased proportions of NKG2C+ cell subsets capable of eliminating HIV-1 infected CD4+ T cells through the TRAIL receptor. In contrast, in non-responder PWH, elevated expression of the inhibitory receptor TIGIT is associated with reduced frequencies of NKG2C+ NK cells and diminished TRAIL expression. TIGIT blockade

SUBMITTER: Ildefonso Sánchez-Cerrillo 

PROVIDER: S-SCDT-10_1038-S44321-025-00255-X | biostudies-other |

REPOSITORIES: biostudies-other