Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity

ABSTRACT: Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a common female-biased disease. ME/CFS diagnosis is hindered by the absence of biomarkers that are unaffected by patients' low physical activity level. Our analysis used semi-parametric efficient estimators, an initial Super Learner fit followed by a one-step correction, three mediators, and natural direct and indirect estimands, to decompose the average effect of ME/CFS status on molecular and cellular traits. For this we used UK Biobank data for up to 1,455 ME/CFS cases and 131,303 controls. Hundreds of traits differed significantly between cases and controls, including 116 significant for both female and male cohorts. These were indicative of chronic inflammation, insulin resistance and liver disease. Nine of 14 traits were

SUBMITTER: Chris, P Ponting 

PROVIDER: S-SCDT-10_1038-S44321-025-00258-8 | biostudies-other |

REPOSITORIES: biostudies-other