Reelin-LRP8 signaling mediates brain dissemination of breast cancer cells via abluminal migration

ABSTRACT: Brain metastasis (BM) remains a significant challenge in breast cancer (BC) management. While conventional metastatic routes primarily involve hematogenous dissemination, emerging evidence suggests that BC cells can also migrate along the abluminal surface of vessels, bypassing the blood-brain barrier (BBB). To investigate this phenomenon, we established a zebrafish xenograft model utilizing GFP-labeled MDA-MB-231 cells, allowing real-time observation of BC cell migration along the posterior cerebral veins. Our findings revealed that LRP8, an apolipoprotein E receptor, is upregulated in BC patients with brain metastasis. Functional studies demonstrated that LRP8 knockdown significantly inhibited proliferation, migration and invasion of triple-negative breast cancer (TNBC) cells both in vit

SUBMITTER: Haofeng Huang 

PROVIDER: S-SCDT-10_1038-S44321-025-00260-0 | biostudies-other |

REPOSITORIES: biostudies-other