LIMA1-alpha staining predicts curative intent surgery response in HPV negative head and neck cancer

ABSTRACT: In many solid cancer types, surgery alone could be sufficient first therapy option for significant number of cancer patients. However, there are currently no diagnostic solutions to identify patients who could be stratified to surgery alone. To identify a biomarker predicting cancer surgery response, candidate biomarkers were studied in non-metastatic head and neck squamous cell carcinoma (nmHNSCC) cohort well representative of HPV negative patient population. LIMA1 immunohistochemistry (IHC) with specificity validated antibodies outperformed all other biomarkers in multivariable survival analyzes of patients with nmHNSCC (n=128, HR 2.10, p=0.006). The prognostic effect was selective to LIMA1-alpha isoform IHC detection in patients who had received surgical therapy (n = 184, HR 2.39, p>

SUBMITTER: Xi Qiao 

PROVIDER: S-SCDT-10_1038-S44321-025-00266-8 | biostudies-other |

REPOSITORIES: biostudies-other