PV-1: A Novel Molecular Prognostic Marker of Distant Metastases in Various Solid Tumors

ABSTRACT: Identification of biomarkers for the hematogenous spreading of cancer cells is of paramount prognostic and therapeutic value. We showed that Plasmalemma Vesicle Associated Protein-1 (PV-1) serves as a marker of increased blood vessel permeability and is an independent predictor of colorectal cancer dissemination. This study investigates whether PV-1 can also act as a prognostic marker for distant metastases in other solid tumors. We analyzed samples from 134 patients: 30 luminal breast cancer (BC), 52 clear cell renal cell carcinoma (ccRCC) and obtained preliminary data from 52 soft tissue sarcomas (STS). A higher frequency of PV-1+ endothelial cells was significantly associated with metastatic progression in luminal BC and ccRCC. Moreover, the frequency of PV-1+ cells emerged as a signifi

SUBMITTER: Chiara Pozzi 

PROVIDER: S-SCDT-10_1038-S44321-025-00277-5 | biostudies-other |

REPOSITORIES: biostudies-other