Dextrorotatory Kynurenine Suppresses Acute Rejection via Inhibiting Macrophage-Mediated Inflammation

ABSTRACT: Acute rejection (AR) remains a critical challenge to graft survival in kidney transplantation. Although dextrorotatory-amino acids (D-AAs) have been recognized as biologically active compounds, their role in mediating immunosuppression was poorly depicted. To address this, serum samples from renal transplant recipients were analyzed via [d0]/[d5]-estradiol-3-benzoate-17β-chloroformate (17β-EBC) based ion mobility-mass spectrometry (IM-MS) to assess D-AAs levels. Additionally, murine skin and kidney transplantation models were utilized to assess the in vivo impact of d-kynurenine (D-Kyn) treatment on AR. We identified D-Kyn as a key metabolite whose elevated levels correlate with stable graft function. We found that D-Kyn, more effectively than its chiral counterpart L-Kyn, inhibits the inf

SUBMITTER: Dong Zhu 

PROVIDER: S-SCDT-10_1038-S44321-026-00377-W | biostudies-other |

REPOSITORIES: biostudies-other