IFN-gene signatures in B cells following influenza A and B virus infection and influenza vaccination

ABSTRACT: Influenza viruses continue to cause a substantial global disease burden. Despite influenza vaccination, some individuals succumb to life-threatening influenza. Yet our understanding of immune features elicited by vaccination and influenza A and B virus infection (IAVs, IBVs) is limited. To define molecular signatures of influenza-specific B-cells, we performed scRNA-sequencing of influenza-specific B-cells in vaccinees and hospitalized IAV/IBV-infected patients using HA-probes. We observed increased interferon-stimulated gene signatures (IF44L, IFITM1 and XAF1), in total B-cells from IBV-patients, but not at 1-month following patients' recovery or in IAV-patients or vaccinees. Phenotypic differentiation and isotype class-switching of HA-specific B-cells were observed following vaccination,

SUBMITTER: Thi Nguyen 

PROVIDER: S-SCDT-10_1038-S44321-026-00395-8 | biostudies-other |

REPOSITORIES: biostudies-other