A skin colonizer disrupts inflammatory and humoral immune defenses in hidradenitis suppurativa

ABSTRACT: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with a polybacterial dysbiosis devoid of a known pathogen. Here, we report that HS patients mount IgA and IgG responses against skin colonizers, notably Porphyromonas uenonis (Pu), a rare species selectively enriched in severe disease. In these patients, Pu foci were detected in the epidermis, surrounded by IgA deposits, and anti-Pu IgGs cross-reacted with self-antigens expressed by healthy keratinocytes. Using healthy human skin explants, we demonstrate that patient-derived Pu can cross an intact epidermal barrier, infect and persist within keratinocytes, triggering their expression of pro-inflammatory mediators. In contrast, topical application of Pu on immunocompetent mice elicited cutaneous and systemic hum

SUBMITTER: Viviane, A Agbogan 

PROVIDER: S-SCDT-10_1038-S44321-026-00407-7 | biostudies-other |

REPOSITORIES: biostudies-other