Impaired vitamin D signaling reveals neutrophils as key drivers of prostate cancer dissemination

ABSTRACT: Prostate cancer (PCa)-related deaths are mainly due to metastasis. The increase in de novo metastatic hormone-naïve PCa (mHNPCs) highlights the urgent need for biomarkers and treatment strategies. We report in a cohort of French PCa patients that the levels of vitamin D and of prostate-specific antigen, the progression biomarker used clinically, are negatively associated. However, the impact of vitamin D receptor (VDR) signaling on prostate tumorigenesis remains unclear. Mice with PTEN inactivation in prostatic epithelial cells (PECs) at adulthood (Pten(i)pe−/− mice) faithfully recapitulate the human disease. We showed that inactivation of PTEN and VDR in PECs promotes tumor aggressiveness. We demonstrate that VDR loss induces oxidative stress, which in turn enhances PECs proliferation. Mo

SUBMITTER: Kateryna Len-Tayon 

PROVIDER: S-SCDT-10_1038-S44321-026-00417-5 | biostudies-other |

REPOSITORIES: biostudies-other