SHP-1 agonist SC-43 limits Methicillin-resistant Staphylococcus aureus infection through inhibition of heme biosynthesis

ABSTRACT: The limitations of existing drugs and the development of drug resistance make it urgent to develop new drugs against methicillin-resistant Staphylococcus aureus (MRSA). The re-development of the antibacterial activity of drugs that have already been proven safe for human use is an effective way. In this study, we discovered that the Src homology region 2 domain-containing phosphatase-1 (SHP-1) agonist SC-43, exhibits potent activity against Gram-positive bacteria, including MRSA. The mode of action studies revealed that SC-43 inhibits the key enzyme coproporphyrin ferrochelatase (CpfC) of the coproporphyrin-dependent (CPD) heme synthesis pathway and interferes with the bacterial porphyrin metabolism. The determination of the structure of CpfC derived from S. aureus (SACpfC) in this study a

SUBMITTER: Wei Huang 

PROVIDER: S-SCDT-10_1038-S44321-026-00418-4 | biostudies-other |

REPOSITORIES: biostudies-other