Immunometabolic Rewiring in Pediatric Obstructive Sleep Apnea Adenoids Across Disease Stages: A Single-Cell Atlas

ABSTRACT: Hypertrophied adenoids in children can impair breathing and lead to obstructive sleep apnea (OSA), often accompanied by abnormal growth and weakened stamina and immunity. However, the cause of the pathological transformation in these originally immune-enhancing lymphoid tissues remains unclear. Our study provides the first single cell transcriptomic and immune repertoire atlas of adenoids from normal snoring to mild, moderate, and severe OSA, and identified markedly asynchronous functional modules, transcriptional regulatory networks and intercellular communications during the progression of OSA. Children with severe OSA exhibited exhibit active Hippo, Notch, and Wnt signaling, alongside significant downregulation of energy synthesis. Analysis revealed compromised T-cell and B-cell immunit

SUBMITTER: Qin Yang 

PROVIDER: S-SCDT-10_1038-S44321-026-00419-3 | biostudies-other |

REPOSITORIES: biostudies-other