Skin-derived G-CSF activates pathological granulopoiesis upon psoriasis

ABSTRACT: Psoriasis is an inflammatory skin disease initiated by environmental triggers and driven by disruption of T cell cytokine network in the cutaneous milieu. The fact that complete resolution of disease by targeting the key inflammatory cytokines remains challenging indicates a contribution of other immune cells to the pathogenesis. Here, we study the role of neutrophils in psoriasis, the first-line innate immune defender that is short-lived but mobile and infiltrative into various tissues. We found that upon psoriasis induction, skin-resident endothelial cells are activated to produce G-CSF which contributes to emergency granulopoiesis in bone marrow, leading to cutaneous accumulation of neutrophil that are functionally inflammatory. Depletion of neutrophils or blockage of psoriasis-driven g

SUBMITTER: Tomson Kosasih 

PROVIDER: S-SCDT-10_1038-S44321-026-00456-Y | biostudies-other |

REPOSITORIES: biostudies-other