Foxs1-mediated transformation of CD34+ fibroblast to myCAFs promotes tumor growth

ABSTRACT: Cancer-associated fibroblasts (CAFs) represent a major structural component of solid tumors and play crucial roles in cancer progression and drug resistance. However, their developmental origin, differentiation trajectory, and therapeutic potential remain poorly defined. Using advanced approaches-including inducible genetic lineage tracing, single-cell RNA sequencing, and spatial transcriptomic profiling-we identified a population of Cd34+Pi16+ fibroblast progenitors (Cd34+ CAFs) in both melanoma and gastric cancer. We delineated their differentiation trajectory toward Acta2+ CAFs, driven by the upregulation of the transcription factor Foxs1. This work establishes the developmental origin of Acta2+ CAFs and experimentally validates the Cd34+ to Acta2+ transition. By reverse-matching the tr

SUBMITTER: Li Zhang 

PROVIDER: S-SCDT-10_1038-S44321-026-00476-8 | biostudies-other |

REPOSITORIES: biostudies-other