Dengue Virus Envelope epitope-specific antibodies are associated with protection from severe dengue

ABSTRACT: Our understanding of a protective humoral immune response to dengue virus (DENV) remains limited. The envelope (E) protein is the main antibody (Ab) target. While anti-fusion loop (FL) epitope monoclonal Abs (mAbs) can induce antibody dependent enhancement (ADE) in vitro, some mAbs targeting quaternary epitopes can cross-neutralize different DENV serotypes. However, the contribution of each Ab subset to disease outcome remains poorly characterized. We defined DENV2 E epitope-specific Abs dynamics and assessed their association with disease outcome in a cohort of hospitalized and subclinical dengue patients during post-primary DENV2 infection. We quantified and isolated anti-E epitope-specific Abs and tested their enhancing and neutralizing capacity. During the critical phase, FL-targeting

SUBMITTER: Sokchea Lay 

PROVIDER: S-SCDT-10_1038-S44321-026-00485-7 | biostudies-other |

REPOSITORIES: biostudies-other