Disease-driven post-transcriptional alterations and alternative splicing of podocytes in FSGS

ABSTRACT: Focal segmental glomerulosclerosis (FSGS) is a major cause of nephrotic syndrome and progression to end-stage renal disease, yet its molecular pathogenesis remains still incompletely defined. While transcriptional alterations in podocytes have been extensively characterized, the contribution of post-transcriptional regulatory mechanisms is poorly understood. Here, we combined a zebrafish podocyte-specific injury model with glomerulus-resolved transcriptomic profiling to dissect RNA regulatory alterations during FSGS progression. Integrated analyses of bulk RNA sequencing, small RNA profiling, and alternative splicing revealed pronounced, time-dependent remodeling of the glomerular transcriptome. Here we show that podocyte injury is associated with loss of key podocyte-specific proteins,

SUBMITTER: Francescapaola Mattias 

PROVIDER: S-SCDT-10_1038-S44321-026-00495-5 | biostudies-other |

REPOSITORIES: biostudies-other