ENDOTHELIAL SLC25A13 LINKS GLUTAMINE METABOLISM TO ANGIOGENESIS

ABSTRACT: Attention to exploring endothelial cell (EC) metabolism is increasing, but a holistic perspective on the metabolic adaptations of ECs during angiogenic proliferation, is still missing. Here, we use a previously in-house developed computational EC-adapted genome scale metabolic model that recapitulates known metabolic features in proliferating ECs to predict novel pathways central to biomass synthesis. We unveil the metabolic function of the glutamate-aspartate antiporter SLC25A13, previously overlooked in ECs, as a key regulator of glutamine utilization and provide evidence regarding its contribution to the generation of cholesterol and other biomass precursors. To our knowledge, predominant SLC25A13-linked utilization of glutamine for cholesterol synthesis has not been reported in other c

SUBMITTER: Abhishek Subramanian 

PROVIDER: S-SCDT-10_1038-S44321-026-00524-3 | biostudies-other |

REPOSITORIES: biostudies-other