Spatiotemporal heterologous vaccination relies on type I interferons at priming to enhance mucosal immunity

ABSTRACT: Parenteral vaccines against respiratory viruses poorly block infection and transmission due to suboptimal induction of mucosal immunity. In contrast, hybrid immunity and heterologous-route immunization regimens generate protective mucosal and systemic immunity. Herein, we examine how chronological order in heterologous prime/boost immunization regimens impacts immune responses using combinations of intramuscular mRNA and intranasal adjuvanted subunit vaccines against SARS-CoV-2. Enhanced long-lived mucosal and systemic immunity depended strongly on vaccine delivery sequence, with heterologous regimens administered in alternate order of routes yielding markedly distinct immune profiles with different Th-biases and divergent localizations. Immunity imparted through heterologous immunization

SUBMITTER: Matthew, J Wiest 

PROVIDER: S-SCDT-10_1038-S44321-026-00539-W | biostudies-other |

REPOSITORIES: biostudies-other