DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T-cell immunity

ABSTRACT: The immunoproteasome is a specialized type of proteasome involved in MHC class I antigen presentation, anti-viral adaptive immunity, autoimmunity and is also part of a broader response to stress. Whether the immunoproteasome is regulated by DNA stress, however, is not known. We here demonstrate that mitochondrial DNA stress upregulates the immunoproteasome and MHC class I antigen presentation pathway via cGAS/STING/type I interferon signaling resulting in cell autonomous activation of CD8+ T cells. The cGAS/STING-induced adaptive immune response is also observed in response to genomic DNA and is conserved in epithelial and mesenchymal cells of mice and men. In patients with idiopathic pulmonary fibrosis, chronic activation of the cGAS/STING-induced adaptive immune response in aberrant lung

SUBMITTER: Dr. Xinyuan Wang 

PROVIDER: S-SCDT-10_15252-EMBJ_2022110597 | biostudies-other |

REPOSITORIES: biostudies-other