The ion channel CALHM6 controls bacterial infection-induced cellular cross-talk at the immunological synapse

ABSTRACT: Membrane ion channels of the calcium homeostasis modulator (CALHM) family promote cell-cell crosstalk at neuronal synapses via ATP release, where ATP acts as a neurotransmitter. CALHM6, the only CALHM highly expressed in immune cells, has been linked to induction of natural killer (NK) cell anti-tumour activity. However, its mechanism of action and broader functions in the immune system remain unclear. Here, we generated Calhm6-/- mice and report that CALHM6 is important for regulation of the early innate control of Listeria monocytogenes infection in vivo. We find that CALHM6 is upregulated in macrophages by pathogen-derived signals, and that it relocates from the intracellular compartment to the macrophage-NK cell synapse, facilitating ATP release and controlling the kinetics of NK cell

SUBMITTER: Dr. Sara Danielli 

PROVIDER: S-SCDT-10_15252-EMBJ_2022111450 | biostudies-other |

REPOSITORIES: biostudies-other