Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens

ABSTRACT: Nucleotide-binding domain leucine-rich repeat (NLR) immune receptors are important components of plant and metazoan innate immunity that can function as individual units or as pairs or networks. Upon activation, NLRs form multiprotein complexes termed resistosomes or inflammasomes. Whereas metazoan paired NLRs, such as NAIP/NLRC4, form hetero-complexes upon activation, the molecular mechanisms underpinning activation of plant paired NLRs, especially whether they associate in resistosome hetero-complexes, is unknown. In asterid plant species, the NLR required for cell death (NRC) immune receptor network is composed of multiple resistance protein sensors and downstream helpers that confer immunity against diverse plant pathogens. Here, we show that pathogen effector-activation of the NLR pro

SUBMITTER: Mr. Mauricio, P Contreras 

PROVIDER: S-SCDT-10_15252-EMBJ_2022111519 | biostudies-other |

REPOSITORIES: biostudies-other