TFEB AND TFE3 CONTROL GLUCOSE HOMEOSTASIS BY REGULATING INSULIN GENE EXPRESSION.

ABSTRACT: To fulfil their function, pancreatic beta-cells require precise nutrient sensing mechanisms that control insulin production. Transcription Factor EB (TFEB) and its homologue TFE3 have emerged as crucial regulators of the adaptive response of cell metabolism to environmental cues. Here we show that TFEB and TFE3 regulate beta-cell function and insulin expression in response to variations in nutrient availability. We found that nutrient deprivation in beta-cells promoted TFEB/TFE3 activation, which resulted in suppression of insulin gene expression. TFEB overexpression was sufficient to inhibit insulin transcription, whereas beta-cells depleted of both TFEB and TFE3 failed to suppress insulin gene expression in response to amino acid deprivation. Interestingly, ChIP-seq analysis showed bindi

SUBMITTER: Dr. Adrien Pasquier 

PROVIDER: S-SCDT-10_15252-EMBJ_2023113928 | biostudies-other |

REPOSITORIES: biostudies-other