LINC00493-encoded microprotein SMIM26 exerts antimetastatic activity in renal cell carcinoma

ABSTRACT: Human microproteins encoded by long noncoding RNAs (lncRNA) have been increasingly discovered, however, complete functional characterization of these emerging proteins is scattered. Here, we show that LINC00493-encoded SMIM26, an understudied microprotein localized in mitochondria, is tendentiously downregulated in clear cell renal cell carcinoma (ccRCC) and correlated with poor overall survival. LINC00493 is recognized by RNA-binding protein PABPC4 and transferred to ribosomes for translation of a 95-amino acid protein SMIM26. SMIM26, but not LINC00493, suppresses ccRCC growth and metastatic lung colonization by interacting with acylglycerol kinase (AGK) and glutathione transport regulator SLC25A11 via its N-terminus. This interaction increases the mitochondrial localization of AGK, and s

SUBMITTER: Dr. Kun Meng 

PROVIDER: S-SCDT-10_15252-EMBR_202256282 | biostudies-other |

REPOSITORIES: biostudies-other