Arginase 1 and L-Arginine Coordinate Fetal Lung Development and the Initiation of Labor in Mice

ABSTRACT: Fetal development and parturition are precisely regulated processes that involve continuous crosstalk between the mother and the fetus. Our previous discovery that wild-type mice carrying steroid receptor coactivator (Src)-1 and Src-2-double-deficient fetuses exhibit impaired lung development and delayed labor indicates that the signals for parturition emanate from the fetus. In this study, we perform RNA sequencing and targeted metabolomics analyses of the lungs from fetal Src-1/-2 double-knockout mice and find that expression of arginase 1 (Arg1) is significantly decreased, accompanied by increased levels of the Arg1 substrate L-arginine. Knockdown of Arg1 in the lungs of fetal mice induces apoptosis of epithelial cells and dramatically delays initiation of labor. Moreover, treatment of

SUBMITTER: Yaqin Yu 

PROVIDER: S-SCDT-10_15252-EMBR_202256352 | biostudies-other |

REPOSITORIES: biostudies-other