Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members

ABSTRACT: The protective and absorptive functions of the intestinal epithelium rely on differentiated enterocytes in the villi. The differentiation of enterocytes is orchestrated by sub-epithelial mesenchymal cells producing distinct ligands along the villus axis, in particular Bmps and Tgfβ. Here we show that individual Bmp ligands and Tgfβ drive distinct enterocytic programs specific to villus zonation. Bmp4 is expressed from the center to the upper part of the villus and activates preferentially genes connected to lipid uptake and metabolism. In contrast, Bmp2 is produced by villus tip mesenchymal cells and it influences the adhesive properties of villus tip epithelial cells and the expression of immunomodulators. Additionally, Tgfβ induces epithelial gene expression programs similar to those tri

SUBMITTER: Linda Berkova 

PROVIDER: S-SCDT-10_15252-EMBR_202256454 | biostudies-other |

REPOSITORIES: biostudies-other