MTORC1 activity negatively regulates human hair follicle growth and pigmentation

ABSTRACT: Dysregulation of the activity of mechanistic target of rapamycin complex 1 (mTORC1) is commonly linked to ageing, cancer and genetic disorders such as tuberous sclerosis (TS), a rare neurodevelopmental multi-systemic disease characterized by benign tumors, seizures and intellectual disability. Although patches of white hair on the scalp (poliosis) are considered as early signs of TS, the underlying molecular mechanisms and potential involvement of mTORC1 in hair depigmentation remain unclear. Here, we use healthy, organ-cultured human scalp hair follicles (HFs) to interrogate the role of mTORC1. Grey/white HFs exhibit high mTORC1 activity, while mTORC1 inhibition by rapamycin stimulated HF growth and pigmentation. Mechanistically, this occurred via increased intrafollicular production of t

SUBMITTER: Takahiro Suzuki 

PROVIDER: S-SCDT-10_15252-EMBR_202256574 | biostudies-other |

REPOSITORIES: biostudies-other