Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia

ABSTRACT: The counterregulatory response to hypoglycemia (CRR), which ensures a sufficient glucose supply to the brain, is an essential survival function. It is orchestrated by incompletely characterized glucose-sensing neurons, which trigger a coordinated autonomous and hormonal response that restores normoglycemia. Here, we investigate the role of hypothalamic Tmem117, identified in a genetic screen as a regulator of CRR. We show that Tmem117 is expressed in vasopressin magnocellular neurons of the hypothalamus. Tmem117 inactivation in these neurons increases hypoglycemia-induced vasopressin secretion leading to higher glucagon secretion in male mice, and this effect is estrus cycle phase-dependent in female mice. Ex vivo electrophysiological analysis, in-situ hybridization and in vivo calcium ima

SUBMITTER: Dr. SEVASTI GASPARI 

PROVIDER: S-SCDT-10_15252-EMBR_202357344 | biostudies-other |

REPOSITORIES: biostudies-other