Macrophages reprogramming improves immunotherapy of IL-33 in peritoneal metastasis of gastric cancer

ABSTRACT: Peritoneal metastasis (PM) has a suppressive tumor immune microenvironment (TIME) that limits the effects of immunotherapy. This study aimed to investigate the immunomodulatory effects of intraperitoneal administration of IL-33 on PM-associated TIME. Immunocompetent mice were used to investigate the role of IL-33 in development of abdominal dissemination and host outcome. Murine (m) and human (h) gastric cancer cells were tested for their response to IL-33 using qRT-PCR, flow cytometry, and immunofluorescence. The survival was significantly prolonged in patients with high IL-33 mRNA expression. Intraperitoneal administration of IL-33 could induce the celiac inflammatory environment, activate immunologic effector cells, and reverse the immunosuppressive tumor microenvironment, which effecti

SUBMITTER: Dr. Keying Che 

PROVIDER: S-SCDT-10_15252-EMMM_202217321 | biostudies-other |

REPOSITORIES: biostudies-other