Multi-omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer

ABSTRACT: Prostate cancer is the most commonly diagnosed malignancy and the third leading cause of cancer deaths. GWAS have identified variants associated with prostate cancer susceptibility, however, mechanistic and functional validation of these mutations are lacking. We used CRISPR-Cas9 genome editing to introduce a missense variant identified in the ELAC2 gene, which encodes a dually localized nuclear and mitochondrial RNA processing enzyme, into the mouse Elac2 gene as well as to generate a prostate-specific knockout of Elac2. These mutations caused enlargement and inflammation of the prostate and nodule formation. The Elac2 variant or knockout mice on the background of the transgenic adenocarcinoma of the mouse prostate (TRAMP) model show that Elac2 mutation with a secondary genetic insult exa

SUBMITTER: Maike Stentenbach 

PROVIDER: S-SCDT-10_15252-EMMM_202317463 | biostudies-other |

REPOSITORIES: biostudies-other