Targeting CD301+ macrophages inhibits endometrial fibrosis and improves pregnancy outcome

ABSTRACT: Macrophages are a key and heterogeneous cell population involved in endometrial repair and regeneration during the menstrual cycle, but their role in the development of intrauterine adhesion (IUA) and sequential endometrial fibrosis remains unclear. Here, we reported that CD301+ macrophages were significantly increased and showed their most active interaction with profibrotic cells in the endometria of IUA patients compared with the normal endometria by single-cell RNA sequencing, bulk RNA sequencing and experimental verification. Increasing CD301+ macrophages promoted the differentiation of endometrial stromal cells into myofibroblasts and resulted in extracellular matrix accumulation, which destroyed the physiological architecture of endometrial tissue, drove endometrial fibrosis and ult

SUBMITTER: Dr. Haining Lv 

PROVIDER: S-SCDT-10_15252-EMMM_202317601 | biostudies-other |

REPOSITORIES: biostudies-other