Sterile triggers drive joint inflammation in TNF and IL-1beta dependent mouse arthritis models

ABSTRACT: Arthritis is the most common extra-intestinal complication in inflammatory bowel disease (IBD). Conversely, arthritis patients are at risk for developing IBD and often display subclinical gut inflammation. These observations suggest a shared disease etiology, commonly termed 'the gut-joint-axis'. The clinical association between gut and joint inflammation is further supported by the success of common therapeutic strategies and microbiota dysbiosis in both conditions. Most data however support a correlative relationship between gut & joint inflammation, while causative evidence is lacking. Using two independent transgenic mouse arthritis models, either TNF- or IL-1dependent, we demonstrate that arthritis develops independently of the microbiota and intestinal inflammation, since both line

SUBMITTER: Ms. Alexandra Thiran 

PROVIDER: S-SCDT-10_15252-EMMM_202317691 | biostudies-other |

REPOSITORIES: biostudies-other