M-CSF directs myeloid and NK cell differentiation to protect from CMV after HCT

ABSTRACT: Therapies reconstituting autologous antiviral immunocompetence may represent an important prophylaxis and treatment for immunosuppressed individuals. Following hematopoietic cell transplantation (HCT), patients are susceptible to Herpesviridae including cytomegalovirus (CMV). We show in a murine model of HCT that macrophage colony-stimulating factor (M-CSF) promoted rapid antiviral activity and protection from viremia caused by murine CMV. M-CSF given at transplantation stimulated sequential myeloid and natural killer (NK) cell differentiation culminating in increased NK cell numbers, production of granzyme B and interferon-g. This depended upon M-CSF-induced myelopoiesis leading to IL15Ra-mediated presentation of IL-15 on monocytes, augmented by type I interferons from plasmacytoid dendri

SUBMITTER: Dr. Prashanth, K. Kandalla 

PROVIDER: S-SCDT-10_15252-EMMM_202317694 | biostudies-other |

REPOSITORIES: biostudies-other