Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation

ABSTRACT: Efficient clearance of dying cells (efferocytosis) is an evolutionarily conserved process for tissue homeostasis. Genetic enhancement of efferocytosis exhibits therapeutic potential for inflammation resolution and tissue repair. However, pharmacological approaches to enhance efferocytosis remain sparse due to a lack of targets for modulation. Here, we report the identification of columbamine (COL) which enhances macrophage-mediated efferocytosis and attenuates intestinal inflammation in a murine colitis model. COL enhances efferocytosis by promoting LC3-associated phagocytosis (LAP), a non-canonical form of autophagy. Transcriptome analysis and pharmacological characterization revealed that COL is a biased agonist that occupies a part of the ligand binding pocket of the formyl peptide rece

SUBMITTER: Dr. Jia-Hong Lu 

PROVIDER: S-SCDT-10_15252-EMMM_202317815 | biostudies-other |

REPOSITORIES: biostudies-other