Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury

ABSTRACT: Following peripheral nerve injury, successful axonal growth and functional recovery require Schwann cell reprogramming into a reparative phenotype, a process dependent upon c-Jun transcription factor activation. Unfortunately, axonal regeneration is greatly impaired in aged organisms and following chronic denervation, which can lead to poor clinical outcomes. While diminished c-Jun expression in Schwann cells has been associated with regenerative failure, it is unclear whether the inability to maintain a repair state is associated with the transition into an axonal growth inhibition phenotype. We here find that reparative Schwann cells transition into a senescent phenotype, characterized by diminished c-Jun expression and secretion of inhibitory factors for axonal regeneration in aging and

SUBMITTER: Dr. Andrés Fuentes-Flores 

PROVIDER: S-SCDT-10_15252-EMMM_202317907 | biostudies-other |

REPOSITORIES: biostudies-other