Neural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma

ABSTRACT: Single-cell RNA sequencing has emerged as a powerful tool for resolving cellular states associated with normal and maligned developmental processes. Here, we used scRNA-seq to examine the cell cycle states of expanding human neural stem cells (hNSCs). From this data, we constructed a cell cycle classifier that identifies traditional cell cycle phases and a putative quiescent-like state in neuroepithelial-derived cell types during mammalian neurogenesis and in gliomas. The Neural G0 markers are enriched with quiescent NSC genes and other neurodevelopmental markers found in non-dividing neural progenitors. Putative glioblastoma stem-like cells were significantly enriched in the Neural G0 cell population. Neural G0 cell populations and gene expression are significantly associated with less ag

SUBMITTER: Ms Samantha, A. O'Connor 

PROVIDER: S-SCDT-10_15252-MSB_20209522 | biostudies-other |

REPOSITORIES: biostudies-other