A Circuit for Secretion-coupled Cellular Autonomy in Multicellular Eukaryotic cells

ABSTRACT: Cancers represent complex autonomous systems, displaying self-sufficiency through its ability to 'secrete-and-sense' growth-factors: a poorly understood phenomenon. Using an integrated systems and experimental approach, here we dissect the impact of a feedback-coupled GTPase circuit within the secretory pathway that imparts secretion-coupled autonomy. The circuit is assembled when the Ras-superfamily monomeric-GTPase Arf1, and heterotrimeric-GTPase Giabg and their corresponding GAPs and GEFs are coupled by GIV/Girdin, a protein that is known to fuel aggressive traits in diverse cancers. One forward and two negative feedback-loops within the circuit create closed-loop control (CLC), allow the two GTPases to coregulate each other, and convert the expected switch-like behavior of Arf1-depende

SUBMITTER: Lingxia Qiao 

PROVIDER: S-SCDT-10_15252-MSB_202211127 | biostudies-other |

REPOSITORIES: biostudies-other