Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering

ABSTRACT: Post-translational modification of proteins by O-linked ?-N-acetylglucosamine (O-GlcNAc) is catalyzed by O-GlcNAc transferases (OGT). O-GlcNAc modification of proteins regulates multiple important biological processes in metazoans. However, whether protein O-GlcNAcylation is involved in epigenetic processes during plant development is largely unknown. Here, we show that loss of function of SECRET AGENT (SEC), an OGT in Arabidopsis, leads to an early flowering phenotype. This results from reduced histone H3 lysine 4 trimethylation (H3K4me3) of FLOWERING LOCUS C (FLC) locus, which encodes a key negative regulator of flowering. SEC activates ARABIDOPSIS HOMOLOG OF TRITHORAX1 (ATX1), a histone lysine methyltransferase (HKMT), through O-GlcNAc modification to augment ATX1-mediated H3K4me3 histo

SUBMITTER: Lijing Xing 

PROVIDER: S-SCDT-EMBOJ-2017-98115 | biostudies-other |

REPOSITORIES: biostudies-other