Wnt/Ca2+ pathway is involved in interneuronal communication mediated by tunneling nanotubes

ABSTRACT: Tunneling nanotubes (TNTs) are actin-based transient tubular connections that allow direct communication between distant cells. TNTs play an important role in several physiological (development, immunity and tissue regeneration) and pathological (cancer, neurodegeneration and pathogens transmission) processes. Here, we report that the Wnt/Ca2+ pathway, an intracellular cascade that is involved in actin cytoskeleton remodeling, has a role in TNT formation and TNT-mediated transfer of cargoes. Specifically, we found that Ca2+/calmodulin-dependent protein kinase II (CaMKII), a transducer of the Wnt/Ca2+ pathway, regulates TNTs in a neuronal cell line and in primary neurons. We identified the ? isoform of CaMKII as a key molecule in modulating TNT formation and transfer, showing that this depe

SUBMITTER: Dr. Jessica, Y Vargas 

PROVIDER: S-SCDT-EMBOJ-2018-101230 | biostudies-other |

REPOSITORIES: biostudies-other