PTX3 regulates synaptic function inducing AMPARs clustering via extracellular matrix and ?1 integrin

ABSTRACT: In the developing central nervous system, the control of synapse number and function are critical to the formation of neural circuits. Astrocytes play a key role in this process by releasing factors, which promote the formation of excitatory synapses. Astrocyte-secreted thrombospondins (TSPs) induce the formation of synapses, which are however post-synaptically silent, suggesting that completion of early synaptogenesis requires a double-step mechanism. Here we show that the humoral innate immune molecule Pentraxin 3 (PTX3) is expressed in the developing rodent brain. PTX3 plays a key role in promoting functionally active CNS synapses, by increasing the surface levels and synaptic clustering of the AMPA glutamate receptors, through a process involving TSG6, the remodeling of the perineurona

SUBMITTER: Dr. Giuliana Fossati 

PROVIDER: S-SCDT-EMBOJ-2018-99529 | biostudies-other |

REPOSITORIES: biostudies-other