YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of stem cells

ABSTRACT: Skeletal muscle satellite cells (SCs) are adult muscle stem cells responsible for muscle regeneration after acute or chronic injuries. The lineage progression of quiescent SC toward activation, proliferation and differentiation during the regeneration is orchestrated by cascades of transcription factors (TFs). Here we elucidate the function of the transcription factor Yin Yang1 (YY1) in muscle regeneration. Muscle-specific deletion of YY1 in embryonic muscle progenitors leads to severe deformity of diaphragm muscle formation thus postnatal death. Inducible deletion of YY1 in SC almost completely blocks the acute damage induced muscle repair and exacerbates the chronic injury induced dystrophic phenotype. Examination of SC revealed that YY1 loss results in cell autonomous defect in activati

SUBMITTER: Dr. Fengyuan Chen 

PROVIDER: S-SCDT-EMBOJ-2018-99727 | biostudies-other |

REPOSITORIES: biostudies-other