Biomechanical stress regulates mammalian tooth replacement via the integrin ?1-RUNX2-Wnt pathway

ABSTRACT: Renewal of integumentary organs occurs cyclically throughout an organism's lifetime, but the mechanism that initiates each cycle remains largely unknown. In a miniature pig model of tooth development that resembles tooth development in humans, the permanent tooth did not begin transitioning from the resting to the initiation stage until the deciduous tooth began to erupt. This eruption released the accumulated mechanical stress inside the mandible. Mechanical stress prevented permanent tooth development by regulating expression and activity of the integrin ?1-ERK1-RUNX2 axis in the surrounding mesenchyme. We observed similar molecular expression patterns in human tooth germs. Importantly, the release of biomechanical stress induced downregulation of RUNX2-wingless/integrated (Wnt) signalin

SUBMITTER: Dr. Xiaoshan Wu 

PROVIDER: S-SCDT-EMBOJ-2019-102374 | biostudies-other |

REPOSITORIES: biostudies-other