Genome-wide cooperation of EMT-transcription factor ZEB1 with YAP and AP-1 in breast cancer

ABSTRACT: Invasion, metastasis and therapy resistance are the major cause of cancer-associated deaths and the EMT-inducing transcription factor ZEB1 is a crucial stimulator of these processes. While work on ZEB1 has mainly focused on its role as a transcriptional repressor, it can also act as a transcriptional activator. To further understand these two modes of action, we performed a genome-wide ZEB1 binding study in triple negative breast cancer cells. We identified ZEB1 as a novel interactor of the AP-1 factors FOSL1 and JUN and show that, together with the Hippo-pathway effector YAP, they form a transactivation complex, predominantly activating tumour promoting genes, thereby synergizing with its function as a repressor of epithelial genes. High expression of ZEB1, YAP, FOSL1 and JUN marks the ag

SUBMITTER: Dr. Simone Brabletz 

PROVIDER: S-SCDT-EMBOJ-2019-103209 | biostudies-other |

REPOSITORIES: biostudies-other