Tudor Staphylococcal Nuclease is a docking platform for stress granule components and is essential for SnRK1 activation in Arabidopsis

ABSTRACT: Tudor Staphylococcal Nuclease (TSN; also known as Tudor-SN, p100 or SND1) is a multifunctional, evolutionarily conserved regulator of gene expression, exhibiting cytoprotective activity in animals and plants and oncogenic activity in mammals. During stress, TSN stably associates with stress granules (SGs), in a poorly understood process . Here, we show that in the model plant Arabidopsis thaliana, TSN is an intrinsically disordered protein (IDP) and acts as a scaffold for a large pool of other IDPs, enriched for conserved SG components as well as novel or plant-specific SG-localized proteins. While approximately 30% of TSN interactors are recruited to stress granules de novo upon stress perception, 70% form a protein-protein interaction network present before the onset of stress. Finally,

SUBMITTER: Prof. Peter, V Bozhkov 

PROVIDER: S-SCDT-EMBOJ-2020-105043P | biostudies-other |

REPOSITORIES: biostudies-other