Regulation of autophagosome biogenesis by OFD1-mediated selective autophagy

ABSTRACT: Autophagy is a lysosome-dependent degradation pathway essential to maintain cellular homeostasis. Therefore, either defective or excessive autophagy may be detrimental for cells and tissues. The past decade was characterized by significant advances in molecular dissection of stimulatory autophagy inputs, however, our understanding of the mechanisms that restrain autophagy is far from complete. Here we describe a negative feedback mechanism that limits autophagosome biogenesis based on the selective autophagy-mediated degradation of ATG13, a component of the ULK1 autophagy initiation complex. We demonstrate that the centrosomal protein OFD1 acts as bona fide autophagy receptor for ATG13 via direct interaction with the Atg8/LC3/GABARAP family of proteins. We also show that patients with Oral

SUBMITTER: Dr. Manuela Morleo 

PROVIDER: S-SCDT-EMBOJ-2020-105120 | biostudies-other |

REPOSITORIES: biostudies-other