Transcytosis via the late endocytic pathway as a cell morphogenetic mechanism

ABSTRACT: Plasma membranes fulfil many physiological functions. In polarized cells, different membrane compartments take on specialized roles, each being allocated correct amounts of membrane. The Drosophila tracheal system, an established tubulogenesis model, contains branched terminal cells with subcellular tubes formed by apical plasma membrane invagination. We show that apical endocytosis and late endosome-mediated trafficking are required for membrane allocation to the apical and basal membrane domains. Basal plasma membrane growth stops if endocytosis is blocked, whereas the apical membrane grows excessively. Plasma membrane is initially delivered apically, and then continuously endocytosed, together with apical and basal cargo. We describe an organelle carrying markers of late endosomes and m

SUBMITTER: Renjith Mathew 

PROVIDER: S-SCDT-EMBOJ-2020-105332 | biostudies-other |

REPOSITORIES: biostudies-other