GSK3?, not GSK3?, drives hippocampal NMDAR-dependent LTD via tau-mediated spine anchoring

ABSTRACT: Glycogen synthase kinase-3 (GSK3) is an important signaling protein in the brain and modulates different forms of synaptic plasticity. Neuronal functions of GSK3 are typically attributed to one of its two isoforms, GSK3?, simply because of its prevalent expression in the brain. Consequently, the importance of isoform-specific functions of GSK3 in synaptic plasticity has not been fully explored. We now directly address this question for NMDA receptor-dependent long-term depression (LTD) in the hippocampus. Here, we specifically target the GSK3 isoforms with shRNA knockdown in mouse hippocampus and with novel isoform-selective drugs to dissect their roles in LTD. Using electrophysiological and live imaging approaches, we find that GSK3?, but not GSK3?, is required for LTD. The specific engag

SUBMITTER: Jonathan, E Draffin 

PROVIDER: S-SCDT-EMBOJ-2020-105513 | biostudies-other |

REPOSITORIES: biostudies-other