BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage

ABSTRACT: Studies of gene-targeted mice identified the roles of the different pro-survival BCL-2 proteins during embryogenesis. However, little is known about the role(s) of these proteins in adults in response to cytotoxic stresses, such as treatment with anti-cancer agents. We investigated the role of BCL-XL in adult mice using a strategy where prior bone marrow transplantation allowed for loss of BCL-XL exclusively in non-hematopoietic tissues to prevent anemia caused by BCL-XL-deficiency in erythroid cells. Unexpectedly, the combination of total-body ?-irradiation (TBI) and genetic loss of Bcl-xl caused secondary anemia resulting from chronic renal failure due to apoptosis of renal tubular epithelium with secondary obstructive nephropathy. These findings identify a critical protective role of BC

SUBMITTER: Dr. Kerstin Brinkmann 

PROVIDER: S-SCDT-EMBOJ-2020-105561 | biostudies-other |

REPOSITORIES: biostudies-other