PTEN? suppresses tumor metastasis through regulation of filopodia formation

ABSTRACT: PTEN is one of the most frequently mutated genes in malignancies and acts as a powerful tumor suppressor. Tumorigenesis is involved in multiple and complex processes including initiation, invasion, and metastasis. The complexity of PTEN function is partially attributed to PTEN family members such as PTEN? and PTEN?. Here, we report the identification of PTEN? (also termed PTEN5), a novel N-terminal-extended PTEN isoform that suppresses tumor invasion and metastasis. We show that the translation of PTEN?/PTEN5 is initiated from the CUG816 codon within the 5'UTR region of PTEN mRNA. PTEN?/PTEN5 mainly localizes in the cell membrane, and physically associates with and dephosphorylates VASP and ACTR2, which govern filopodia formation and cell motility. We found that endogenous depletion of PTE

SUBMITTER: Prof. Yuxin Yin 

PROVIDER: S-SCDT-EMBOJ-2020-105806 | biostudies-other |

REPOSITORIES: biostudies-other