Alarmin S100A9 restricts retroviral infection by limiting reverse transcription in human dendritic cells

ABSTRACT: Dendritic cells (DC) subsets, like Langerhans cells (LC), are immune cells involved in pathogen sensing. They express specific antimicrobial cellular factors that are able to restrict infection and limit further pathogen transmission. Here, we identify the alarmin S100A9 as a novel intracellular antiretroviral factor expressed in human monocyte-derived and skin-derived LC. The intracellular expression of S100A9 is decreased upon LC maturation and inversely correlates with enhanced susceptibility to HIV-1 infection of LC. Furthermore, silencing of S100A9 in primary human LC relieves HIV-1 restriction while ectopic expression of S100A9 in various cell lines promotes intrinsic resistance to both HIV-1 and MLV infection by acting on reverse transcription. Mechanistically, the intracellular exp

SUBMITTER: Dr. Ghizlane Maarifi 

PROVIDER: S-SCDT-EMBOJ-2020-106540 | biostudies-other |

REPOSITORIES: biostudies-other