Photoreceptor nanotubes mediate the in vivo exchange of intracellular material

ABSTRACT: Emerging evidence suggests that intracellular molecules and organelles transfer between cells during embryonic development, tissue homeostasis and disease. We and others recently showed that transplanted and host photoreceptors engage in bidirectional transfer of intracellular material in the recipient retina, a process termed material transfer (MT). We used cell transplantation, advanced tissue imaging approaches, genetic and pharmacologic interventions and primary cell culture to characterize and elucidate the mechanism of MT. We show that MT correlates with donor cell persistence and the accumulation of donor-derived proteins, mitochondria and transcripts in acceptor cells in vivo. MT requires cell contact in vitro and is associated with the formation of stable microtubule-containing

SUBMITTER: Dr. Arturo Ortin Martinez 

PROVIDER: S-SCDT-EMBOJ-2020-107264 | biostudies-other |

REPOSITORIES: biostudies-other