Host autophagy mediates organ wasting and nutrient mobilization for tumor growth

ABSTRACT: During tumor growth, when nutrient and anabolic demands are high, autophagy supports tumor metabolism and growth through lysosomal organelle turnover and nutrient recycling. Ras-driven tumors additionally invoke non-autonomous autophagy in the microenvironment to support tumor growth, in part through transfer of amino acids. Here, using a well-characterized malignant tumor model in Drosophila melanogaster, we uncover a third critical role of autophagy in mediating systemic organ wasting and nutrient mobilization for tumor growth. Micro-computed X-ray tomography and metabolic profiling reveal that RasV12; scrib-/- tumors grow ten-fold in volume, while systemic organ wasting unfolds with progressive muscle atrophy, loss of body mass, motility, feeding and eventually death. Tissue wasting is

SUBMITTER: Dr. Tor Erik Rusten 

PROVIDER: S-SCDT-EMBOJ-2020-107336 | biostudies-other |

REPOSITORIES: biostudies-other